Diagnosis & Treatment


Marfan syndrome and related connective tissue conditions are diagnosed in a number of ways. At Hoag, we offer a dedicated clinic to expertly diagnose these conditions, utilizing:

  • Physical exam
  • Echocardiogram
  • Genetic testing & family history review
  • Advanced imaging including 3D CT and MRI

Although, there is no curative treatment for Marfan syndrome and related conditions yet, with proper medical management and surveillance we can greatly improve quality of life and restore longevity to near normal. Our goal at Hoag is to have each of our patients live the longest and fullest life possible.

Toward that goal, Hoag Marfan Syndrome and Related Conditions Program in the Elaine & Robert Matranga Aortic Center offers:

  • Ongoing medical guidance and management
  • Blood pressure management
  • In clinic echocardiogram
  • On site 3D Imaging Lab evaluation
  • State-of-the-art surveillance
  • Surgical consultation

The program is led by Cardiovascular Specialist David Liang, M.D., Ph.D. who is internationally recognized for his care of patients with Marfan syndrome and related connective tissue conditions. Dr. Liang brings 25 years of experience with Marfan syndrome and related conditions.

Marfan syndrome patients are at an increased risk for aortic disease – when the aorta enlarges and the walls of the aorta are thinned. This can lead to aortic dissection (a tear) or rupture, which requires expert surgical care. Hoag’s Elaine & Robert Matranga Aortic Center is one of few centers in Southern California to provide a comprehensive approach to aortic disease. Hoag has three cardiothoracic surgeons dedicated to elective and emergency surgery, Anthony Caffarelli, M.D., director of Hoag Cardiovascular Surgery, director of the Elaine & Robert Matranga Aortic Center and the Newkirk Family Endowed Chair in Aortic Care; Asad Shah, M.D., chair of the Department of Cardiovascular Surgery and director of Robotic Cardiac Surgery at Hoag; and Timothy Lee, M.D. They bring the full spectrum of aortic surgery expertise, including valve-sparing aortic root replacement surgery which restores patients with aortic root aneurysms near-normal life avoiding the use of blood thinners.

Marfan syndrome and related conditions impact the entire body, so the program incorporates ophthalmologists, orthopedists, maternal-fetal medicine specialists, genetic counselors, podiatrists, and physical therapists to provide coordinated and specialized care.

Genetics are at the root of many of these conditions. Using genetic testing, the precise nature of these conditions can be characterized. Understanding the interpretation of genetic testing however, requires expertise in separating normal human variation from disease-causing mutations. Hoag’s Marfan Program includes geneticists, genetic counselors, and cardiologists that can put the results of genetic testing into the proper perspective for you.

Contact Us

For more information on Marfan Syndrome and Related Conditions Program, please call 949-764-8468 or contact us.