Thyroid

• (167-17) Caris ctDNA Validation Project (Research study, appropriate for patients with all solid tumors.)

• (175-17) A randomized phase II study comparing selumetinib to placebo for enhancing the clinical efficacy of radioactive iodine (RAI) for recurrent/metastatic thyroid cancers that retain RAI uptake (Phase 2 clinical trial, appropriate for patients with thyroid cancer.) Principal Investigator: Michael J. Demeure, M.D., F.A.C.S., F.A.C.E.; Sub-Principal Investigator: George B. Semeniuk, M.D.

• (211-17) Pharmacokinetic and Safety Study of Niraparib With Normal or Moderate Hepatic Impairment Patients (Phase 1 clinical trial, appropriate for patients with advanced solid tumors.)