Duopa Treatment

DuopaTM is a new approach to the delivery of carbidopa and levodopa for the treatment of motor fluctuations in patients with advanced Parkinson's disease.

Although Duopa contains the same active ingredients as orally administered carbidopa/levodopa immediate-release tablets, it is not a pill. It is a gel suspension of carbidopa and levodopa that is delivered in a continuous fashion throughout the day, which helps to reduce the off time symptoms often experienced with oral medications.

How Duopa Works

In the advanced stages of Parkinson’s disease, patients may begin to experience “off” time, or periods of poor mobility, rigidity, slowness and stiffness. Additionally, in Parkinson’s disease patients, the spontaneous emptying of the stomach becomes delayed and unpredictable, which can affect the timing of when orally-administered medications leave the stomach and are absorbed in the small intestine.

Duopa provides a promising new treatment option for Parkinson's disease patients suffering from these motor fluctuations and other disabling symptoms, because it’s administered directly into the small intestine, bypassing the stomach, through a procedurally placed tube connected to a portable infusion pump. This new method of delivery enables patients to receive a continuous dose of carbidopa and levodopa for up to 16 hours daily.

Key Benefits of Duopa Treatment

  • Duopa is the first and only treatment providing 16 continuous hours of carbidopa and levodopa for motor fluctuations in advanced Parkinson's disease.

  • In clinical trials, patients treated with Duopa experienced significantly greater improvement in "off" time than patients treated with oral carbidopa-levodopa immediate-release tablets.

Who is a Candidate for Duopa Treatment?

Duopa is an FDA-approved treatment that is generally recommended for use in patients with advanced Parkinson's disease who still respond to carbidopa-levodopa, but are experiencing increased fluctuations in their response to the oral medication. Because Duopa is continually infused directly into the small intestine, it helps to maintain a continuous supply of carbidopa and levodopa, which may result in significantly less "off" time symptoms.

For more information about Duopa treatment, contact your Hoag-affiliated neurologist or call Hoag Parkinson’s and Movement Disorders Program at 949-764-6066.