DuopaTM is a new approach to the delivery of carbidopa and levodopa for the treatment
of motor fluctuations in patients with advanced Parkinson's disease.
Although Duopa contains the same active ingredients as orally administered
carbidopa/levodopa immediate-release tablets, it is not a pill. It is
a gel suspension of carbidopa and levodopa that is delivered in a continuous
fashion throughout the day, which helps to reduce the off time symptoms
often experienced with oral medications.
How Duopa Works
In the advanced stages of Parkinson’s disease, patients may begin
to experience “off” time, or periods of poor mobility, rigidity,
slowness and stiffness. Additionally, in Parkinson’s disease patients,
the spontaneous emptying of the stomach becomes delayed and unpredictable,
which can affect the timing of when orally-administered medications leave
the stomach and are absorbed in the small intestine.
Duopa provides a promising new treatment option for Parkinson's disease
patients suffering from these motor fluctuations and other disabling symptoms,
because it’s administered directly into the small intestine, bypassing
the stomach, through a procedurally placed tube connected to a portable
infusion pump. This new method of delivery enables patients to receive
a continuous dose of carbidopa and levodopa for up to 16 hours daily.
Key Benefits of Duopa Treatment
Duopa is the first and only treatment providing 16 continuous hours of
carbidopa and levodopa for motor fluctuations in advanced Parkinson's disease.
In clinical trials, patients treated with Duopa experienced significantly
greater improvement in "off" time than patients treated with
oral carbidopa-levodopa immediate-release tablets.
Who is a Candidate for Duopa Treatment?
Duopa is an FDA-approved treatment that is generally recommended for use
in patients with advanced Parkinson's disease who still respond to
carbidopa-levodopa, but are experiencing increased fluctuations in their
response to the oral medication. Because Duopa is continually infused
directly into the small intestine, it helps to maintain a continuous supply
of carbidopa and levodopa, which may result in significantly less "off"
For more information about Duopa treatment, contact your Hoag-affiliated
neurologist or call Hoag Parkinson’s and Movement Disorders Program at