Simon Khagi, MD

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Simon Khagi, MD



  • Hoag Specialty Clinic


  • English

About Dr. Khagi

Simon Khagi, MD, is Director of Neuro-Oncology at Hoag Family Cancer Institute and a triple-board certified medical oncologist and neuro-oncologist. Dr. Khagi’s areas of expertise include treating primary brain and spine cancers, as well as thoracic cancers and melanoma. His areas of expertise include: immunotherapy, genomically-guided therapy, oncolytic virotherapy, adoptive cell therapy (i.e. CAR T cells), alternating tumor treating fields, glioblastoma, astrocytoma, oligodendroglioma, meningioma, ependymoma, medulloblastoma, germ cell tumors, brain metastases, rare brain tumors, lung cancer, melanoma, advanced skin cancer. Dr. Khagi has always felt a strong connection with patients and families battling cancer. The desire to help them motivated him to become an oncologist. According to Dr. Khagi, he considers quality and quantity of life as two sides of the same coin when supporting his patients. Valuing both is a cornerstone of the care he provides.

Previously, Dr. Khagi was an Assistant Professor of Medicine at the Geisel School of Medicine at Dartmouth. He also served as an Associate Oncology Service Line Director and Regional Medical Director at Dartmouth Cancer Center. Prior to joining Dartmouth, Dr. Khagi served as the Director of the Neuro-Oncology and Brain Metastases Program at the University of North Carolina at Chapel Hill UNC.

Dr. Khagi is active in clinical research, having conducted numerous clinical trials focusing on glioblastoma, meningioma, advanced glioma, and brain metastases, among others. While at UNC, he led many novel research protocols, including the first institutional use of a live virus delivered directly into the brain against brain tumors, in addition to contributing to the development of a novel CAR T cell technology for glioblastoma. To date, Dr. Khagi has authored or co-authored over fifty book chapters, peer-reviewed manuscripts and abstracts. Having received multiple honors throughout his career and being inducted as a fellow of the American College of Physicians, Dr. Khagi has also received the “Healthcare Hero Award” from the Head for the Cure Foundation and the “Exemplary Service Award” from the UNC Division of Medical Oncology along with multiple research grants.

Dr. Khagi feels strongly about raising awareness of the societal burden of cancer and speaks regularly at community outreach events, in addition to sitting on multiple organizational boards focused on improving cancer care.


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National Provider ID (NPI): 1710121165


Board Certification

  • American Board of Internal Medicine - Medical Oncology
  • Medical Education - University of Missouri-Kansas City School of Medicine
  • Residency - Dartmouth Hitchcock Medical Center (Internal Medicine)
  • Fellowship - Tufts Medical Center (Hematology and Medical Oncology)
  • Fellowship - Duke University School of Medicine (Neurological Oncology)


  • Hoag Specialty Clinic

Area of Focus

  • Oncology/Hematology