Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.

Pregnant and/or lactating women

Patients included in any other interventional trial

Use of endotracheal intubation and mechanical ventilation or extracorporeal membrane oxygenation (ECMO) at screening

Any concurrent serious medical condition or concomitant medication that would preclude participation in the study including but not limited to:

• Septic shock as defined by systolic blood pressure (SBP) < 90 mmHg or diastolic blood pressure (DBP) of < 60 mmHg;
• Multiple organ failure;
• Are moribund irrespective of the provision of treatments;
• Any significant bleeding disorder or vasculitis;
• Any serious, nonhealing wound, peptic ulcer or bone fracture;
• Liver cirrhosis;
• History of a hypertensive crisis or hypertensive encephalopathy, or current, poorly controlled hypertension or hypotension;
• Severe renal insufficiency or end stage renal disease as determined by estimated glomerular filtration rate <30mL/min/1.73m2;
• ARDS risk factors of aspiration pneumonia, non-cardiac shock, trauma, blood transfusion or drug overdose.

Any thromboembolic event within the past 3 months;

Symptomatic congestive heart failure or symptomatic or poorly controlled cardiac arrhythmia > class II as per New York Heart Association (NYHA) classification;

History of autonomic disorders or uncontrolled hypotension

Hypersensitivity to drug products containing polyethylene glycol (PEG)

Any other condition which the Principal Investigator feels may jeopardize the safety of the patient or the objectives of the study