Neurosciences Clinical Trials
Prior Risk and Early Detection Of Multiple Sclerosis (the PREDOMS) study
What is the purpose of this study?
The objectives of this study are: • To identify biomarkers in healthy controls with high risk of developing MS to predict their risk of future development or early onset of MS. • To identify novel antibodies for early detection of MS. • To validate the RIMS index.
Eligibility
Inclusion Criteria for First Degree Group
1. Age 18-50 years old
2. Have confirmed biological full first-degree relative(s) with a confirmed diagnosis of MS
3. Documented diagnosis by referring physician or health record evidence of a first degree relative with MS
4. Ability to give blood samples regularly for the duration of the study
5. Ability to consent for the study including genetic testing
Inclusion Criteria for Healthy Control Group
1. Age 18-50 years old
2. No diagnosis of MS, any other demyelinating disease, any other neurological disease, any immunological disease, any active malignancy and no family history of MS
3. Ability to give blood samples regularly for the duration of the study
4. Ability to consent for the study including genetic testing
1. Previous demyelinating event or clinical documentation of abnormal brain MRI
2. History of any other autoimmune disease that is active
3. History of active malignancy
4. Pregnant subjects
5. Subjects receiving or have received any form of immunomodulating, immunosuppressant or chemotherapy in the 3 months prior to the study, for long term effect agents such as CD20 depleting therapies (6 months)
6. History of bone marrow transplant, chemotherapy or long-term effect immunosuppressants such as cladribine, alemtuzumab, cyclophosphamide, mitozantrone.
Where can I participate?
Hoag Hospital Newport Beach
1 Hoag
Newport Beach, CA 92663
What is the full name of this Clinical Trial?
Prior Risk and Early Detection Of Multiple Sclerosis (the PREDOMS) study
- Disease Type/ConditionMultiple Sclerosis
- Principal InvestigatorYasir N. Jassam MD
- Co-InvestigatorsSourat Darabi, Ph.D. , Junko Hara, Ph.D. , Carlos Zuazo, M.Sc, Chelsey Torres, M.S., C.G.C., Jonathan Lin, M.S., C.G.C., Emily Chien, M.S., C.G.C. , Phillip Stafford, Ph.D.
- Age GroupAdult, Older Adult
- How do I learn more about this study?Laurie Hendricks, MSN, RN, OCN
laurie.hendricks@hoag.org
https://www.hoag.org/institute/neurosciences/
Hoag’s Pickup Family Neurosciences Institute offers Orange County’s most comprehensive neurologic care, with multidisciplinary specialists, advanced technology, and evidence-based treatment for complex brain, spine, and nervous system conditions. Patients have access to leading programs in brain tumors, memory and cognitive disorders, multiple sclerosis, epilepsy, Parkinson’s and movement disorders, headache and migraine, stroke, and clinical trials.
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