Multiple Sclerosis & Neuroimmunology Program

At the Pickup Family Neurosciences Institute, we pride ourselves in offering a team of multiple sclerosis doctor and specialists who are dedicated to helping patients at any stage of their disease journey. This comprehensive and integrated approach to care lessens the burden of the disease on patients and caregivers. Because there is no cure for MS, ongoing medical treatment for multiple sclerosis is required and available for patients to maintain the best quality of life. Our team specializes in the assessment and treatment of patients affected by this disease based on the disease stage and their individual needs.

In addition to medication, our providers work closely with physical therapists, occupational therapists, dietary services, OB/GYN providers and gastrointestional providers. Working as a comprehensive team to manage your symptoms and slow down the progression of MS.

Getting an accurate diagnosis of multiple sclerosis (MS) is one of the most important steps in your care journey. Because MS can mimic other neurological conditions, it requires specialized testing, advanced imaging, and expert evaluation by a neurologist who understands the complexities of this disease. At Hoag, our MS & Neuroimmunology Program is dedicated to providing clarity and confidence for patients seeking answers.

Why Accurate Diagnosis Matters

A misdiagnosis can delay the right treatment, cause unnecessary exposure to medications, and allow MS to progress unchecked. Early, precise diagnosis ensures that treatment can begin sooner, helping to preserve brain and spinal cord function and prevent long-term disability.

Advanced Imaging with Icometrix

Hoag is one of the few centers to integrate Icometrix, an advanced artificial intelligence tool that enhances MRI imaging. This technology provides detailed measurements of brain volume, lesion load, and subtle changes that may not be visible on standard scans. By using Icometrix, our specialists gain a clearer picture of disease activity, making it possible to diagnose MS earlier and track its progression with greater accuracy. While this technology enhances the imaging of the brain, it's the specialist who makes the diagnosis based on years of training and understanding of multiple sclerosis and how the lesions present on these images.

The Role of a Specialist Neurologist

MS is a complex disease that requires the expertise of a neurologist trained in MS and neuroimmunology. General neurology care may miss subtle signs or lead to delays in diagnosis. At Hoag, our patients benefit from comprehensive evaluations that consider medical history, neurological exam, bloodwork, spinal fluid analysis, and advanced imaging. This thorough process reduces the risk of misdiagnosis and ensures the most effective treatment plan.

What to Expect in the Diagnostic Process

At Hoag, your evaluation may include:

• Detailed neurological exam – assessing strength, coordination, reflexes, vision, and sensation.

• Advanced MRI scans with Icometrix – providing objective measurements of brain and spinal cord changes.

• Lumbar puncture (spinal fluid test) – detecting inflammatory markers that support MS diagnosis.

• Blood tests – ruling out other autoimmune or infectious conditions that can mimic MS.

This comprehensive approach allows us to move beyond uncertainty and provide a clear diagnosis, so you and your care team can begin building a personalized treatment plan.

Why Choose Hoag

With advanced imaging, world-class expertise, and a patient-first philosophy, Hoag offers one of the most trusted MS diagnostic programs in the region. Our goal is not only to identify the disease accurately but also to guide patients with compassion and clarity from the very first appointment.

While there is no cure for multiple sclerosis (MS), there are many effective treatments that can slow the progression of the disease, reduce relapses, and improve quality of life. At Hoag, we personalize each care plan to meet the unique needs of every patient.

Advancing the Future of MS Care Through Innovation

Thanks to the generosity of the Hoag Foundation Innovators Fund for Research, Dr. Yasir Jassam and the Hoag MS & Neuroimmunology Program are leading the way in redefining how multiple sclerosis (MS) is diagnosed, treated, and even predicted. Dr. Jassam takes a three-pronged approach that combines the latest technology with forward-thinking research to improve the lives of people living with MS:

Improving Precision Medicine

Every person with MS experiences the disease differently, which is why personalized care is so important. At Hoag, patients benefit from advanced tools like the Octave blood test—a first in Southern California—that can determine the stage of disease, and ICOMETRIX MRI technology, which can reveal hidden signs of chronic active MS that standard scans often miss. By identifying the “central vein sign,” these scans help distinguish MS from other brain conditions, reducing the risk of misdiagnosis and ensuring patients get the right treatment sooner.

A View Into the Future

Hoag is one of the select sites actively testing new therapies that aim to change the course of MS. Current clinical trials include medications for both relapsing and progressive forms of the disease, such as Remibrutinib (REMODEL-2) and Frexalimab (FREVIVA). These studies open doors to treatment options that may not be available anywhere else and give patients early access to therapies that could improve their long-term outcomes.

Predicting and Preventing MS Before It Starts

In an ambitious effort to stop MS before symptoms appear, Dr. Jassam is developing a Risk Index for MS (RIMS)—a scoring system that combines genetics, environment, lifestyle, and other known risk factors. When paired with blood biomarkers, this tool could identify individuals at high risk for developing MS, offering the possibility of early intervention years before the disease takes hold.

Together, these initiatives reflect Dr. Jassam’s bold vision: treat MS early, treat it aggressively when appropriate, and tailor care to each individual so they can achieve No Evidence of Disease Activity (NEDA)—the best possible outcome for patients today, and a brighter future for tomorrow.